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Thursday, August 6, 2020 | History

2 edition of New synthesis of naphthoquinones found in the catalog.

New synthesis of naphthoquinones

Stephen W Heinzman

New synthesis of naphthoquinones

by Stephen W Heinzman

  • 290 Want to read
  • 39 Currently reading

Published .
Written in English

    Subjects:
  • Kalafungin,
  • Antibiotics -- Synthesis,
  • Naphthoquinone

  • Edition Notes

    Statementby Stephen W. Heinzman
    The Physical Object
    Pagination69 leaves :
    Number of Pages69
    ID Numbers
    Open LibraryOL14439743M

    Title:Natural Naphthoquinones with Great Importance in Medicinal Chemistry VOLUME: 13 ISSUE: 3 Author(s):Fernando de Carvalho da Silva and Vitor Francisco Ferreira Affiliation:Universidade Federal Fluminense, Instituto de Química, Campus do Valonguinho, Niterói, RJ, Brasil. Keywords: β-lapachone, lapachol, lawsone, derivatives, biological activities, synthesis. We performed an extensive analysis about the reaction conditions of the 1,4-Michael addition of amino acids to 1,4-naphthoquinone and substitution to 2,3-dichloronaphthoquinone, and a complete evaluation of stoichiometry, use of different bases, and the pH influence was performed. We were able to show that microwave-assisted synthesis is the best method for the synthesis of naphthoquinone.

    Scheme 3: Synthesis of naphthoquinones 3 and 4. CONCLUSION In this work we report the synthesis of new naphthoquinones derives from lawsone, both in moderate yields. The products 3 and 4 presented antifungal activity against Candida krusei . Book October with Reads How we measure 'reads' A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure.

    In this research, we reported the study and synthesis of naphthoquinones intermediate compounds lead to the target naphthoquinones derivatives product. Naphthoquinones derivatives have long been known to display anticancer and antimalarial activity in addition to a wide variety of other bioactivities. Moreover, it has been reported to possess antimalarial disease against Plasmodium falciparum. The prognosis of this disease is poor and the choice of effective medicines limited, thus study of new drugs is absolutely necessary. In this work, the activities of three new pyrazolylnaphthoquinones, heterocyclic naphthoquinones bearing 3-aminopyrazole rings, were evaluated on Trypanosoma cruzi, the etiological agent of Chagas' disease.


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New synthesis of naphthoquinones by Stephen W Heinzman Download PDF EPUB FB2

Thieme E-Books & E-Journals. Abstract. The preparation of naphthoquinones by oxidation of 1-tetralone derivatives is reported. 1,2-Naphthoquinones were prepared by oxidation with IBX and 1,4-naphthoquinones were prepared by oxidation using Oxone ® and 2-iodobenzoic acid.

The mechanistic pathways are also by: 8. Palladium-catalyzed synthesis of o -acetylbenzoic acids: a new, efficient general route to 2-hydroxyphenyl-1,4-naphthoquinones and indolo[2,3- b ]naphthalene-6,diones.

Tetrahedron Letters43 (29), Cited by:   A New Synthesis of Benzo[f ]isoindole‐4,9‐diones by Radical Alkylation and Bromomethylation of 1,4‐Naphthoquinones Jurgen Deblander Laboratory of Organic Chemistry, Department of Applied Biological Sciences and Engineering, Faculty of Science and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, Brussels, Belgium.

Naphthoquinones constitute the largest and diverse groups of plant secondary metabolites many of which have biological activities, including antimicrobial, antifeedant, and allelopathic activities.

Mamoru Tabata, in Phytochemicals in Plant Cell Cultures, C Glycosides of Oxygenated Naphthalenes. Naphthoquinones usually do not occur as glycosides in higher plants.

However, Müller and Leistner () isolated not only 1,4-naphthoquinone (10) and juglone (11) but also new glucosides of the corresponding hydroquinones (12, 13) from mesocarp callus and cell-suspension cultures of.

One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones Yassine Bendiabdellah, Isabel Villanueva-Margalef, Antonio Misale, Kazi S.

Nahar, Mohammad R. Haque, David E. Thurston, Giovanna Zinzalla*. Related Books SoS C-1 Building Blocks in Organic Synthesis SoS Multicomponent Reactions A New Direct Synthesis of Aminoquinones Shmuel Bittner *, Dorit Lempert A novel one-step amination of 1,4-naphthoquinones and 1,4-benzoquinones is described.

Satyavan Sharma, Nitya Anand, in Pharmacochemistry Library, 3 NAPHTHOQUINONES. The importance of naphthoquinones, particularly 2-hydroxyalkyl-1,4-naphthoquinones, in chemotherapy of malaria came to light when a naphthoquinone, hydrolapachol (9), was found to possess activity against P.

lophurae in ducks [8].This observation prompted Fieser and coworkers [9–13] to synthesize a series. Synthesis, a series of books developed by the Science History Institute, seeks to shed light on the history of chemistry, broadly construed, and its diverse roles in society.

Contributors include top scholars in the history of science and a number of past recipients of Beckman Center for the History of Chemistry fellowships. The series is published by the University of Chicago. Sociobiology: The New Synthesis AuthorEdward O.

Wilson CountryUnited States LanguageEnglish SubjectSociobiology PublisherHarvard University Press Publication date Media typePrint Pages ISBN OCLC Dewey Decimal 21 LC ClassQLW54 Preceded byThe Insect Societies Followed byOn Human Nature Sociobiology: The New Synthesis is a book by the biologist E.

Wilson. Title:Synthesis and Biological Evaluation of New Naphthoquinones Derivatives VOLUME: 17 ISSUE: 3 Author(s):El-Mahdi Ourhzif, Caroline Decombat, Isabelle Abrunhosa-Thomas, Laetitia Delort, Mostafa Khouili, Mohamed Akssira *, Florence Caldefie-Chezet, Pierre Chalard and Yves Troin* Affiliation:Universite Clermont Auvergne, CNRS, SIGMA Clermont, ICCF, F Clermont-Ferrand.

New Dyes Based on Extended Fulvene Motifs: Synthesis through Redox Reactions of Naphthoquinones with Donor–Acceptor Cyclopropanes and Their Spectroelectrochemical Behavior - Lücht - - Chemistry – A European Journal - Wiley Online Library.

A structured review of the biological properties and synthesis of naphthoquinones, focusing on the structure of 2-hydroxy-1,4-naphthoquinone (lawsone) and its derivatives has been presented.

A series of 1,4-naphthoquinones and related products has been synthesized to study their mode of action in bacterial growth inhibition. The in vitro reactions of a number of these with aniline, n-butylamine, sodium methoxide, and an n-buthanethiol–triethylamine mixture have been examined.A series of epoxides of C-2 monosubstituted and C-2,C-3 disubstituted 1,4-naphthoquinones has been.

Guang Huang, Jin-Yun Dong, Qi-Jing Zhang, Qing-Qing Meng, Hui-Ran Zhao, Bao-Quan Zhu, Shao-Shun Li, Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents, European Journal of Medicinal Chemistry, /, ().

We have reported a simple and clean methodology for the synthesis of bis-naphthoquinones in aqueous media in the first series. We have used LiCl as catalyst. Other catalysts also used in place of LiCl are like LiNO 3, NaCl, KCl, NH 4Cl, Na 2SO 4, p-TSA, and HCl but it.

naphthoquinones, a promising group of compounds already shown to have antibacterial (6, 7), anti-fungal (), antiviral (11, 12), antitumor () and antimalarial () activities, among others.

We present a structured review on the chemistry of naphthoquinones, focusing on 2-hydroxy-1,4-naphthoquinone (lawsone) and the synthesis of.

Design and development of drugs in multi-drug resistant (MDR) infections have been of growing interest. We report the syntheses, and antibacterial and antifungal activities of imidazole-based 1,4-naphthoquinones (I-1 to I-4; 1-alkylmethyl-1H-naphtho[2,3-d]imidazole-4,9-dione (alkyl = methyl to butyl)) and their precursors (B-3; N-(3-chloro-1,-dioxo-1,4-dihydronaphthalenyl)acetamide) and.

1,4-naphthoquinone is the parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring.

Derivatives have pharmacological properties. It derives from a hydride of a naphthalene. Abstract Taking into account the numerous reports in the literature related to pyran naphthoquinones in searching for new pharmacologically promising molecules against different therapeutic targets, this review intends to explore the synthetic methodologies for preparing these bioactive compounds.

METHOD: Synthesis of new naphtoquinones derivatives and in vitro evaluation of their cytotoxicity on MCF-7 cells (rezasurin cell-based assay).

RESULTS: Starting from Ethyl 4-hydroxy-6,7-dimethoxynaphthoate, four naphthoquinones were prepared and exhibited substantial cytotoxicity against MCF-7 cells. The 1,4-naphthoquinones (1,4-NQs) are a diverse group of natural products found in every kingdom of life.

Plants, including many horticultural species, collectively synthesize hundreds of.The syntheses, physico-chemical characterization and cytotoxicity toward three human cell lines (standard and resistant sarcoma cells, and fibroblast) of a new copper(II) complex [Cu(HBPA)(L1)Cl]3H 2 O 2 are reported.

Complex 2 was obtained through the reaction between the ligand stilbene-quinone (HL1) and Cu[HBPA]Cl 2 1, where HBPA = 2-hydroxybenzyl-2pyridylmethylamine.